June 4, 2002 case 68 yo wf with hx of htn and dm presents to er after a fall. Heparin induced thrombocytopenia hit is an adverse effect of heparin therapy with possibly devastating consequences. Heparin induced thrombocytopenia adult inpatient clinical. Heparininduced thrombocytopenia hit is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets thrombocytopenia. Time to think patient education treatment of hit disease process treatment ss related to complications activity. Consequently, heparin induced thrombocytopenia hit, an immune complication of heparin therapy, remains a highly relevant complication for the hematology practitioner to diagnose and manage. Heparin and platelet factor 4 pf4 are capable of forming multimolecular. Definition of hit heparininduced thrombocytopenia is an antibody mediated prothrombotic disorder. Case studies in heparininduced thrombocytopenia springerlink.
Heparininduced thrombocytopenia genetic and rare diseases. The following guideline is intended to guide the management of heparin induced thrombocytopenia and includes recommendations for diagnosis and treatment agents. Download bleeding disorders thrombocytopenia medical. Heparininduced thrombocytopenia hit is a lifethreatening complication of exposure to heparin eg, unfractionated heparin, low molecular weight lmw heparin that occurs in a small percentage of. Her only presenting complaints were incisional leg pain and vague chest discomfort. Historical and clinical perspectives diovision of cardiology beth israel deaconess medical center boston heparin induced thrombocytopenia heparin as a cause of thrombosis and the hit syndromes powerpoint ppt presentation free to view. Overview of heparininduced thrombocytopenia medscape. Heparininduced thrombocytopenia blood american society. Here, we present illustrative case histories to educate the reader on evaluation and management of this complex syndrome. It is associated with significant morbidity and mortality if unrecognized. View and download powerpoint presentations on low molecular weight heparin ppt. Ppt heparininduced thrombocytopenia hit powerpoint. Heparin induced thrombocytopenia hit is the most important and most frequent drug induced, immunemediated type of thrombocytopenia. Heparininduced thrombocytopenia type ii hit is a more serious autoimmune disease causing a low platelet count and paradoxical blood clotting.
Heparin induced thrombocytopenia hit is the development of thrombocytopenia a low platelet count, due to the administration of various forms of heparin, an anticoagulant. Garciab abstract heparin induced thrombocytopenia hit is an adverse. Mechanism and clinical presentation of heparininduced thrombocytopenia heparininduced thrombocytopenia hit is a potentially lifethreatening complication of heparin anticoagulation. The treatment of hit is then discussed, with an emphasis on current therapies. Target population adult patients with suspicion or diagnosis of heparin induced thrombocytopenia key practice recommendations screening for hit 1. Heparininduced thrombocytopenia a disease of 100 days 2. Heparin induced thrombocytopenia powerpoint ppt presentation. Heparininduced thrombocytopenia hit syndrome that occurs in 15% of all heparinexposed patients immunemediated formation of igg antibodies to heparinplatelet factor 4 pf4 complexes pf4 is. A free powerpoint ppt presentation displayed as a flash slide show on id. Heparin induced thrombocytopenia, or hit, can present in many ways, ranging from commonisolated thrombocytopenia, venous thromboembolism, acute limb ischemiato less common but specific. Ppt heparin induced thrombocytopenia powerpoint presentation. John francis, phd, discusses the pathophysiology of heparininduced thrombocytopenia hit, its clinical and laboratory diagnosis, the immunobiology of hit antibodies, thrombin formation and treatment. Heparininduced thrombocytopenia hit is the development of thrombocytopenia a low platelet count, due to the administration of various forms of heparin, an anticoagulant. Thrombocytopenia, a frequently occurring complication of heparin therapy and known as heparin induced thrombocytopenia hit may occur in 2 distinct types.
Furthermore, thrombocytopenia is commonly associated with bleeding. Heparininduced thrombocytopenia immune thrombocytopenic purpura infection e. Download presentation note the pptpdf document heparin induced thrombocytopenia is the property of its rightful owner. The primary clinical presentation of hit is thrombocytopenia, usually with a. Clinical presentation of heparininduced thrombocytopenia. Clinical features that help distinguish hit from other forms of thrombocytopenia include the timing of onset and the presence of thrombosis eg, venous thromboembolism or other. Heparin induced thrombocytopenia hit medical powerpoint. Consequently, heparininduced thrombocytopenia hit, an immune complication of heparin therapy, remains a highly relevant complication for the hematology practitioner to diagnose and manage. Find powerpoint presentations and slides using the power of, find free presentations research about low molecular weight heparin ppt. Understanding heparin induced thrombocytopenia hit. Dosedependent myelosuppression and immune destruction of the platelets are two wellknown causes. Heparininduced thrombocytopenia hit, an antibodymediated syndrome, is. Heparininduced thrombocytopenia is a profoundly dangerous, potentially lethal, immunologically mediated adverse drug reaction to unfractionated heparin or, less commonly, to lowmolecular weight heparin.
Download free medical bleeding disorders thrombocytopenia. Riia on platelets and monocytes to propagate a hypercoagulable state culminating in lifethreatening thrombosis. Heparininduced thrombocytopenia powerpoint presentation. May 03, 2012 heparin induced thrombocytopenia hit is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets thrombocytopenia. Presented live at the 2012 caseoriented symposium on bleeding and thrombosis in arlington, va.
Drugs may cause thrombocytopenia by different mechanisms. This cardiology patient page focuses on heparininduced thrombocytopenia hit, a complication of heparin therapy. Heparininduced thrombocytopenia type ii occurs in 15% of patients started on heparin. Download heparininduced thrombocytopenia ppt for free. Heparininduced thrombocytopenia and thrombosis syndrome was diagnosed in a 63yearold woman 11 days after coronary artery bypass grafting. Delayedonset heparininduced thrombocytopenia and thrombosis. Permission is granted to download and print the materials on this web site for personal, noncommercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all.
Heparin induced thrombocytopenia hit presentation transcript. Heparin induced thrombocytopenia hit is a lifethreatening complication of exposure to heparin eg, unfractionated heparin, low molecular weight lmw heparin that occurs in a small percentage of patients exposed, regardless of the dose, schedule, or route of administration. The syndrome was suspected when her platelet count was found to be 37,000. One of these is heparininduced thrombocytopenia hit, a common, serious and potentially lifethreatening condition 1,2, and one for which diagnosis can be dif. Pathophysiology, clinical implications, therapy, and cases view slides download in powerpoint ppt format.
Heparininduced thrombocytopenia dr vinod hit an immunoglobulinmediated adverse drug reaction characterized by. An iv or central line that is flushed with heparin or coated with heparin. Heparininduced thrombocytopenia type i is harmless, causing a mild and transient reduction in platelet count. Heparininduced thrombocytopenia hit is a condition that causes a decrease of platelets in the blood. Heparininduced thrombocytopenia rn continued education. Type ii heparin induced thrombocytopenia hit is an immunological disorder characterized by antibodies to heparin platelet factor 4 complexes and a high risk of thrombotic complications. Heparin induced thrombocytopenia when an individual has a platelet count less than 150,000 plateletsul, he or she is considered to have thrombocytopenia. Lachant, md chief, section of hematology director, thrombosis program associate director, hematologic malignancy program a free powerpoint ppt presentation displayed as a flash slide show on id. James zehnder, md, professor of pathology and hematology at stanford university discusses the pathophysiology, clinical features, diagnosis and management of heparin. Heparininduced thrombocytopenia hit ppt video online download. The use of heparin exposes patients to heparininduced thrombocytopenia, which is a challenging issue for both diagnosis and patient management. Her only presenting complaints were incisional leg pain and.
Etiology severity clinical presentation evaluation treatment comments. Presentation, management and outcome of heparininduced. The more common, type i sometimes called heparin associated thrombocytopenia, occurs in approximately 10% to 20% of patients receiving heparin, 1 and is a nonimmunogenic response to therapy. The objectives of this study are to determine the effect of heparin induced thrombocytopenia hit on postoperative morbidity and mortality after cardiac surgery and to identify preoperative risk factors for hit. Heparin induced thrombocytopenia hit is an immunemediated adverse effect of heparin that is important because of its relatively high frequency and its strong association with paradoxic venous and. Ppt heparin powerpoint presentation free to download. Hit is usually an immune response which typically occurs 410 days after exposure to heparin. Thrombocytopenia, a frequently occurring complication of heparin therapy and known as heparininduced thrombocytopenia hit may occur in 2 distinct types. Clinical presentation and diagnosis of heparin induced thrombocytopenia. Heparininduced thrombocytopenia what you need to know.
Feb 03, 2020 heparin induced thrombocytopenia hit is a condition that causes a decrease of platelets in the blood. Hit predisposes to thrombosis the abnormal formation of blood clots inside a blood vessel because platelets release microparticles that activate thrombin, thereby. Mechanism and clinical presentation of heparininduced thrombocytopenia heparininduced thrombocytopenia hit is a potentially lifethreatening complication of heparin anticoagulation, occurring in approximately 3% of patients treated with unfractionated heparin. Bleeding complications are a primary safety concern with the use of heparin therapy.
Jan 17, 2012 heparin induced thrombocytopenia hit is an adverse effect of heparin therapy with possibly devastating consequences. A subsequent ventilationperfusion lung scan showed findings highly probable for pulmonary. Heparin induced thrombocytopenia hit medical powerpoint presentation 8. Heparin induced thrombocytopenia thrombosis tissue. Heparin induced thrombocytopenia heparin induced thrombocytopenia hit is characterized by a decrease in the platelet count of more than 50% from the highest platelet count value after the start of heparin, an onset 5 to 10 days after the start of heparin, hypercoagulability, and the presence of heparin dependent, platelet activating igg. Pathogenic antibodies to pf4heparin bind and activate cellular fc. Free download bleeding disorders thrombocytopenia powerpoint presentation. Heparin induced thrombocytopenia jennifer howard d. Heparin induced thrombocytopenia hit syndrome that occurs in 15% of all heparin exposed patients immunemediated formation of igg antibodies to heparin platelet factor 4 pf4 complexes pf4 is released from platelet granules and is positively charged heparin is negatively charged.
One of the most severe and lifethreatening immune thrombocytopenias is heparin induced thrombocytopenia hit, an immunemediated disorder caused by antibodies that recognize a neoepitope. Heparin induced thrombocytopenia free download as powerpoint presentation. Heparin induced thrombocytopenia hit two forms hit type i nonimmune, caused by direct effect of heparin on plt activation, lesser fall in platelet count that. Heparininduced thrombocytopenia thrombocytopenia presentation displayed as a flash slide show on id. Dager, in chemistry and biology of heparin and heparan sulfate, 2005. Find powerpoint presentations and slides using the power of, find free presentations research about. May 03, 2020 the use of heparin to treat and prevent thromboembolic disorders is well established, with use of more than 1 trillion units in the united states annually.
Furthermore, thrombocytopenia is commonly associated with bleeding complications. Thrombocytopenia is a serious condition in which patients have a low platelet count. An onset 5 to 10 days after the start of heparin 3. The most commonly used intravenous anticoagulant is heparin. Heparin induced thrombocytopenia online presentation tools. Permission is granted to download and print the materials on this web. Heparin induced thrombocytopenia a disease of 100 days 2.
A decrease in the platelet count of more than 50% from the highest platelet count value after the start of heparin 2. Ppt heparininduced thrombocytopenia powerpoint presentation. Displaying powerpoint presentation on heparininduced thrombocytopenia available to view or download. Christian rodriguez jeannie wade nina pereira jessica jeanbaptiste jump into patho teaching time. Heparin induced thrombocytopeia hit linkedin slideshare. Impact of heparininduced thrombocytopenia on postoperative. John francis, phd, discusses the pathophysiology of heparin induced thrombocytopenia hit, its clinical and laboratory diagnosis, the immunobiology of hit antibodies, thrombin formation and treatment options. Heparin induced thrombocytopenia powerpoint presentation. Hit usually occurs after you are treated with heparin.
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